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AN601 images
3D EM of Brain Tissue Using Automated Tissue Processing

From 4-5 days down to <1 day

Serial block-face electron microscopy (SBEM, or 3D EM) provides powerful 3D insight into neurological structures for mapping and quantification. While image acquisition is now largely computer controlled, sample prep continues to be manually intensive, taking up to a week of exchanges of toxic reagents. In this poster, Cleveland Clinic researchers report a protocol using the mPrep™ ASP-1000 that reduces a 4-5 day manual sample prep protocol to less than a day of automated processing with equivalent results (as seen in the micrographs on the left).


M&M 2022 Call for Papers – Submit by Feb 17

The call for papers for the M&M 2022 Conference, scheduled for Jul 31– Aug 4 in Portland, OR, is currently open. Deadline to submit is Feb 17. Two sessions of note in biological symposia:

B07: 3D Volume Electron Microscopy in Biological Research
  • Challenges and advancement in sample preparation for volume EM (vEM)
  • Innovation in combined vEM and Correlative Light and Electron Microscopy (CLEM) workflow
  • Application of vEM techniques in biomedical research
  • Techniques, instrumentation, and software development for vEM image acquisition and analysis
B10: Development, Challenges and Biomedical Applications of Tissue Clearing, Expansion Microscopy and Volumetric Imaging
  • Development and applications of tissue clearing technologies in biological specimens
  • Advancement in expansion microscopy technologies and their biomedical applications
  • Progress on tissue staining and advanced tissue preparation methods and hardware advancements inspired by novel tissue preparation protocols
  • Development of computational approaches for storing, processing, visualizing large volumetric image data


BioEM Talks video
Need a (Robotic) Hand?

We’ve seen a lot of EM job listings on the MSA website, Microscopy ListServer, and LinkedIn …

Consider automated processing!
The mPrep ASP-1000 Automated Specimen Processor is like an extra set of hands to prepare specimens, keeping you distant from toxic fumes, and enabling you to avoid the tedium of manual specimen prep and accomplish other work. Check it out or give us a call!


NSF logo
Have a research need, problem, or an idea?
Consider working with Microscopy Innovations. Contact us to discuss the potential for collaborative funding on NIH, DoD or NSF grants!

Here's just one example ... from National Science Foundation

NSF 21-502 Infrastructure Innovation for Biological Research
This program supports research to design novel or greatly improved research tools and methods that advance contemporary biology in any research area supported by the Directorate for Biological Sciences at NSF. The Innovation Program focuses on research infrastructure that is broadly applicable to researchers in three programmatic areas: Bioinformatics, Instrumentation, and Research Methods.
Awards range between $300K - $800K.


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NSF logo
Grant Funding to Get Started Automating Your Specimen Prep

If you want to improve EM lab efficiency and workflow through automation, grants are available to help. Automation with the mPrep ASP-1000 helps core labs meet client needs efficiently with current staffing levels, while adding the ability to handle more 3D EM or immunolabelling specimens.

Here are couple of current grant
opportunities to fund instrument purchases
Shared Instrumentation Grant (SIG) Program
The Shared Instrument Grant (SIG) Program encourages applications to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. Awards range between $50K and $600K.

National Science Foundation
NSF 21-501 Infrastructure Capacity for Biological Research
The Infrastructure Capacity for Biological Research (Capacity) Program supports the implementation of, scaling of, or major improvements to research tools, products, and services that advance contemporary biology in any research area supported by the Directorate for Biological Sciences at NSF. Awards range between $25K and $1.2M.


Microscopy Innovations LLC

Creating 21st Century EM Lab Products to Accelerate Science

213 Air Park Road, Suite 101, Marshfield, WI 54449

Phone +1 715-384-3292 | |

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